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It is also not recommended for use in patients with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2, as semaglutide may increase the risk of these conditions

Nonetheless, contemporary research is still nascent, necessitating more clinical studies to substantiate their efficacy, resolve concerns about strain selection and dose optimization, and facilitate the clinical implementation of GM-directed therapeutics for OP management (263)

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Buckner TW, Ataga KI (2014) Does hydroxyurea prevent pulmonary complications of sickle cell disease