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Because retatrutide has no approved label, no established contraindications, warnings, monitoring requirements, or dosing instructions exist outside a trial one reason obtaining it outside research is unsafe

This degree of weight loss can shift patients from severe to mild OSA, or from mild OSA to below the diagnostic threshold entirely

With this context, we also discuss some unresolved questions with regard to the potential benefits of GLP-1 agonists on the neurovascular unit (NVU), and provide examples of novel experimental paradigms that could be useful in improving our understanding regarding the neuroprotective mode of action associated with these agents

Methods 9 , 671675 (2012)