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2017;8(1):e2537
Mutation in mitochondrial ribosomal protein MRPS22 leads to Cornelia de Lange-like phenotype, brain abnormalities and hypertrophic cardiomyopathy
The GHK part is a three amino acid peptide of glycine-histidine-lysine that can be found naturally in yucky bodily fluids (if you are wondering in plasma, saliva, and urine)
The downregulation of inflammatory markers (e.g., NF-B, IL-1, TNF-) during this phase aligns with an upregulation of chondrogenic genes such as COL2A1 (collagen type II) and ACAN (aggrecan), which are indispensable for restoring the functional properties of hyaline cartilage
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