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Data indicate interactions with pathways involved in neurotransmission regulation, oxidative stress modulation, and maintenance of neuronal structural components

Background on 5-Reductase 5-reductase exists in two main isoforms: Type I (5AR1): found mainly in skin, scalp, and sebaceous glands

As GLP-1RAs continue to reshape the management of metabolic disease, understanding their potential ocular effects will be essential for both clinicians and regulators.

This mobile redox active arm can transfer electrons to the incoming oxidized Trx or internally to the Grx domain (C28/C31) of the partner subunit where reduction of oxidized glutathione (GSSG) occurs