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Macrophages As the body's initial line of defense in the innate immune response, macrophages are crucial for controlling host inflammation and preserving tissue homeostasis [68]

Statements Author contributions AS: Conceptualization, Visualization, Resources, Validation, Formal Analysis, Project administration, Methodology, Data curation, Writing review & editing, Funding acquisition, Writing original draft, Investigation, Supervision, Software

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These advancements, summarized in Table 1, demonstrate significant progress in predictive olfactory models while also highlighting the persistent challenges of fully capturing the multidimensional complexity of odorant properties