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Other Orange / reddish-brown urine discoloration (harmless) Fatigue Increased sweating Rare but serious: Severe diarrhea dehydration Hepatotoxicity (rare compared to Tolcapone) --- 8

Yet in places where, because of a better diet or for other reasons, high cholesterol is less common, APOE4 is either less of a risk factor for Alzheimers (like in East-Asians) or not at all (like in Africas Bushmen) (Notkola et al., 1998)

Physical activity levels also influence reported outcomes, with both highly active individuals and sedentary people reporting benefits, though for different reasons

What can vary slightly is shipping speed