PubMed: 18436195Clinical (RCT / meta-analysis) ref-8.Shahbazian H, Shayanpour S, Ghorbani A Evaluation of administration of oral N-acetylcysteine to reduce oxidative stress in chronic hemodialysis patients: A double-blind, randomized, controlled clinical trial
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American Association for Cancer Research, 2005
In addition, AMP-activated protein kinase (AMPK) inhibits mTOR, thereby affecting the PI3K-AKT pathway, which is involved in the regulation of fibrosis ( FIGURE 2 Traditional Chinese Medicine (TCM) has emerged as a promising adjunctive therapy for renal fibrosis, leveraging its pleiotropic mechanisms to restore biological homeostasis