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Similarly, dietary approaches that increase NO precursors or mitigate oxidative stress (such as dietary nitrate, CIT/L-arginine, and antioxidant polyphenols) can improve exercise-induced enhancements in endothelial function and microvascular blood flow, thereby augmenting substrate delivery to trained musculature and enhancing training responsiveness in geriatric populations (81)

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Molecular weight approximately 1,419 Da, small enough to cross most biological barriers including the blood-brain barrier in animal models