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Slightly positive or near-neutral zeta potentials (approximately 10 to +10 mV) are generally preferred for systemic administration because highly cationic particles can strongly bind to the negatively charged endothelial glycocalyx and plasma proteins, causing aggregation, complement activation, and membrane damage (120)

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Die wissenschaftliche Evidenz fr diese Anwendungen ist allerdings begrenzt

Mimics and models of glutathione peroxidase 2.1 Ebselen analogues as GPx mimics/models Synthetic selenium compounds with significant GPx activity have potential therapeutic applications (Figure 3)