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These responses work to help the liver maintain its function of detoxifying impurities by neutralizing free radicals produced in the liver and preventing stress which leads to cell damage and contributes to the development of liver diseases

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Moreover, sitagliptin reduced TNF or LPS-induced cellular reactive oxygen species (ROS) level, cell apoptosis, and protein expression in the NFB signaling pathway in HepG2 cells or primary mouse hepatocytes

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