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The bioavailability difference between the two routes compounds the distinction: topical application creates a localized skin depot, while injection delivers the peptide systemically at concentrations impossible to achieve through the skin barrier

Mingrone G, Panunzi S, De Gaetano A et al (2021) Metabolic surgery versus conventional medical therapy in patients with type 2 diabetes: 10-year follow-up of an open-label, single-centre, randomised controlled trial

Amylin receptor signaling in the ventral tegmental area is physiologically relevant for the control of food intake

Similar results were obtained in a third placebo-controlled study of liraglutide 1.8 mg, which also employed 24-h ambulatory HR monitoring in overweight or obese hypertensive subjects with T2DM (n = 17)