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Studies have shown that JAK2 may also phosphorylate insulin receptor substrate 1/2 (IRS1/2) and activate the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) pathway (Ridderstrale et al., 1995

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Pharma now needs to work hard to present a more complete picture of obesity management: where it fits within the pantheon of related metabolic and cardiovascular diseases, and how GLP-1s can still play a pivotal role in treatment, beyond weight loss alone