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Ferroptosis is a form of regulated cell death initiated by iron- or copper-mediated lipid peroxidation

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Empirical evidence indicates that dietary supplementation with nickel chloride at concentrations of 300, 600, and 900 mg/kg NiCI2 feed results in a marked reduction in total erythrocyte count (TEC), hemoglobin (Hb) concentration, and packed cell volume (PCV) in broilers, while concomitantly increasing erythrocyte osmotic fragility (EOF), thereby indicating significant hematological alterations

Dickinson D a, Moellering DR, lies KE, et al