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However, glucagon itself has recently been shown to be able to stimulate insulin secretion from the perfused mouse pancreas by a mechanism which appears to involve an interaction with GLP-1 receptors (since the effect was attenuated by exendin 9-39) (111), complicating assessment of the relative importance of any locally produced GLP-1

Acknowledgements This study has been delivered through the NIHR Manchester Biomedical Research Centre (BRC) (NIHR203308)

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