glp 1 osa GLP-1 receptor agonists, SGLT-2 inhibitors, and obstructive sleep apnoea: can new allies face an old enemy? Latest Insights on GLP-1 Therapy

Although significant progress has been made in the research on the pathogenesis of neurodegenerative diseases such as Alzheimers disease, Parkinsons disease, amyotrophic lateral sclerosis and Huntingtons disease, and many drugs have found neuroprotective effects in cells and animal models, but there is still no drug that can produce clinical changes significantly in the pathogenesis

at the same time, since the intracerebral hematoma releases hemoglobin (Hb)-based neurotoxin (Wang 2010), the neural damages secondary to perihematomal edema (PHE) that is caused by BBB disruption also occur in the brain parenchyma, becoming an important cause of morbidity and mortality in patients (Jeon et al., 2021)

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According to the researchers, it didn't matter if the patient was obese or not before taking the GLP-1 -- the benefits in terms of clot risk were similar