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Persons taking most antibiotics, methotrexate and pyrimethamine invalidate folic acid and Vitamin B12 diagnostic blood assays

1 Even though this slowdown in gut motility is by design, it also may be the reason many people on GLP-1 medications experience some initial digestive disturbances and discomfort

NICE guidance (NG49 and DG34) recommends that patients with NAFLD undergo assessment of fibrosis risk using non-invasive scores such as the FIB-4 or NAFLD fibrosis score, with age-appropriate cut-offs

What that looks like in practice: some people notice shifts in energy and how their body composition responds before the scale moves much, since the goal is metabolic, not just water weight