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This treatment is rarely used because the depigmentation is permanent and the skin without pigment is vulnerable to damage from sun exposure

World J Gastroenterol: WJG 12(13):2034 Ercan G, Tartar RI, Solmaz A, Gulcicek OB, Karagulle OO, Meric S et al (2020) Potent therapeutic effects of ruscogenin on gastric ulcer established by acetic acid

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