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ROS stimulate the production of transforming growth factor- (TGF-), a major mediator of fibrosis ( Moreover, oxidative stress disrupts the balance between matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs), critical for collagen turnover and tissue remodeling ( 3 Therapeutic agents for oxidative stress in TAO and their potential therapeutic targets 3.1 Application of antioxidants TAO exhibits dysregulation of oxidative stress pathways, which can be targeted to mitigate oxidative damage and restore redox balance ( Figure 2 )

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, Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation, J