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This approach also helps us explore the links between defective autophagy and various diseases, including neurodegeneration and cancer

Ozone decreases the production of pro-inflammatory cytokinesparticularly IL-6, IL-1, and TNF-which are primarily responsible for cartilage degradation

Other key interactions include a hydrogen bond between the carbonyl oxygen and Arg125 and a salt bridge between the amino group and residues Glu205 and Glu206 as illustrated in (Figure 2)