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CONTRA-INDICATIONS Hypersensitivity to Menadione sodium bisulfite

13 In 1993, The Journal of Clinical Apheresis published a paper detailing the use of TPE as either a first- or second-line therapy to be used with other modalities on disorders such as Raynauds disease, systemic lupus erythematosus, coagulation factor inhibitors, familial hypercholesterolemia, acute Guillain-Barr syndrome, chronic inflammatory demyelinating polyneuropathy, myasthenia gravis, cryoglobulinemia, Goodpastures syndrome, and thrombotic thrombocytopenic purpura

2019;11(12) doi: 10.3390/nu11122971

Furthermore, another study in zebrafish also found that exposure to concentrated copper (111000 g/L) led to faster heart rates at 28 h postfertilization (hpf) zebrafish embryos, suggesting a stress response in fish embryos [35]