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For example, a mutated form of human 2 AR lacking a consensus PKA phosphorylation site [13] localized to one specific residue [16] had no effect on the ability of the receptor to mediate agonist-stimulation of adenylyl cyclase or undergo rapid internalization, but had an impairment in receptor phosphorylation and desensitization

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DOQ and AM can react and conjugate with many biomolecules, including protein residues cysteine and tyrosine with sulfhydryl and hydroxyl groups, whereas polymerization of AM will form neuromelanin (NM), an insoluble granular pigment in SN [5, 25, 26]

doi:10.3389/fnut.2019.00093