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Eur J Med Chem 152:600614 Sozio P, DAurizio E, Iannitelli A, Cataldi A, Zara S, Cantalamessa F, Nasuti C, Di Stefano A (2010) Ibuprofen and lipoic acid diamides as codrugs with neuroprotective activity

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This parameter has been further studied, showing that those men and women in the lowest quartile of the IGF-1/IGFBP3 ratio are threefold more likely to meet the Adult Treatment Panel III (ATP-III) definition for MetS, and twice as likely to be insulin resistantthat IGF-1/IGFBP-3 ratio decreases notably as the number of MetS components increases [217]

Choline is a nutrient that helps the body metabolize fat