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As a central transcription factor to mediate cellular adaptation to hypoxia, early upregulation of HIF-1 may play a compensatory protective role (Jiang et al., 2020)

One is a hormonally active, FDA-approved metabolic drug with robust human evidence

Using hyaluronic acid on completely dry skin in low-humidity environments can potentially draw moisture from deeper skin layers, leading to temporary tightness or dryness