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Moreover, glutathione itself is known to also be produced rhythmically and so the same logic applies to any NRF2 activator when viewed as a therapeutic in this disease context

The problem with glutathione is that it is an amino acid just like many of the proteins we consume

Neurochem Res 40:25272543 Higgins RD, Raju T, Edwards AD, Azzopardi DV, Bose CL, Clark RH, Ferriero DM, Guillet R, Gunn AJ, Hagberg H, Hirtz D, Inder TE, Jacobs SE, Jenkins D, Juul S, Laptook AR, Lucey JF, Maze M, Palmer C, Papile L, Pfister RH, Robertson NJ, Rutherford M, Shankaran S, Silverstein FS, Soll RF, Thoresen M, Walsh WF (2011) Hypothermia and other treatment options for neonatal encephalopathy: an executive summary of the Eunice Kennedy Shriver NICHD workshop

The net result is the tendency to increase body weight