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It also modulates matrix metalloproteinases (MMPs) and their inhibitors (TIMPs), which helps clear damaged proteins and prevent excessive breakdown of the extracellular matrix
However, the SPH domain lacks proteolytic activity due to a mutation of the catalytic residues
These benefits are valuable as chronic inflammation and oxidative damage have been linked to aging and reduced tissue repair
Gopal Grandhige, MD, FACS, Board-Certified Surgeon Last Reviewed: June 5, 2026 MOTS-C can be stacked with several other peptides, and the pairings that hold up best are the ones built on completely different biological mechanisms
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