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The pair, along with colleague John Eng, identified a hormone-like molecule in the venom called exendin-4, which stimulated insulin secretion using the same receptor as a human gut hormone called GLP-1 (glucagon-like peptide 1)

Adjust meal composition (add lean protein and healthy fats) rather than abandoning exercise

Survodutide activates glucagon receptors in the liver, directly stimulating hepatic fat oxidation

The insulinotropic effects of GIP are dramatically attenuated in T2D patients (52, 53), and this is believed to be a major contributing factor to impaired postprandial insulin secretion in these individuals