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In addition, disruptions in mitochondrial Fe-S cluster biosynthesis lead to the activation of the iron starvation response, elevating intracellular iron levels and the susceptibility to ferroptosis 221,222

Inconsistent storage creates inconsistent dosing, which creates inconsistent results, which makes it nearly impossible to optimize your protocol because you cannot tell whether the problem is the dose or the storage

The use of human MNCs were approved by the Ethics Committee of Kiel University under informed consent from healthy donors

In a 26-week rat oral toxicity study, AOD-9604 produced dose-dependent changes in serum osteocalcin (a bone-turnover marker) at week 13, with the direction reversing by week 26