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( C ) IB analysis using specific Abs against Vcam1, Icam1, and Tbx in isolated aortas from WT and 4.2 / mice treated with vehicle or mitapivat (100 mg/kg/d) for 6 months

Abbreviations IL-1: Interleukin-1 IL-2: Interleukin-2 IL-4: Interleukin-4 IL-6: Interleukin-6 IL-7: Interleukin-7 IL-8: Interleukin-8 IL-10: Interleukin-10 IL-12: Interleukin-12 IL-15: Interleukin-15 IL-17: Interleukin-17 IL-18: Interleukin-18 IL-20: Interleukin-20 IL-21: Interleukin-21 IL-22: Interleukin-22 IL-23: Interleukin-23 IL-27: Interleukin-27 IL-33: Interleukin-33 IL-37: Interleukin-37 GM-CSF: Granulocytemacrophage colony-stimulating factor MIG: Monokine induced by gamma IP-10: Interferon gamma-induced protein 10 TGF-1: Transforming growth factor-beta 1 TNF-: Tumour necrosis factor-alpha IFN-: Interferon-gamma JAK/STAT: Janus kinase/signal transducer and activator of transcription SMAD2/3: Suppressor of mothers against decapentaplegic 2/3 NLRP3: Nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 TIMP2: Tissue inhibitor of metalloproteinases 2 PCNA: Proliferating cell nuclear antigen SOCS3: Suppressor of cytokine signalling 3 FVWFs: Female vaginal wall fibroblasts BMSCs: Bone marrow mesenchymal stem cells MDSC: Myeloid-derived suppressor cells PCL/PLGA-BCP: Polycaprolactone/poly(lactide-co-glycolide) biphasic tricalcium phosphate References ACOG Practice Bulletin No