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Highlights of Prescribing Information: Fortamet (metformin hydrochloride) extended-release tablets, for oral use

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A particularly concerning condition associated with these drugs is stomach paralysis, or gastroparesis, a chronic condition where the stomach takes longer to empty its contents and potentially leads to blockages, resulting in significant discomfort and potentially severe complications

This anatomical change does not interfere with the absorption or efficacy of Rybelsus, which is absorbed primarily in the stomach, facilitated by the absorption enhancer SNAC (salcaprozate sodium)