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In this signalling the IGF-1 receptor (IGF-1R) is unquestionable, the predominating single factor

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37 Similarly, in a retrospective cohort study of 3435 people with type 2 diabetes exposed to tirzepatide for 180 days and over compared with a matched unexposed cohort, tirzepatide was associated with an increased risk of new-onset proliferative diabetic retinopathy primarily in those with pre-existing nonproliferative diabetic retinopathy

doi: 10.3390/microorganisms9050968 94 PatmoreLAKatwaroeWKvan der SpekDChoiHSJPatelKBrakenhoffSet al