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Patients often report a reduction in weight as well as an increase in energy levels, making it easier to tackle daily activities and exercise routines

Thus, the association of Shank3 with mitochondrial proteins and processes, including the mitochondrial ETC activity, has been established, although the mechanisms connecting SHANKs and mitochondria at the excitatory synapses remain unknown

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142 Activity-dependent mRNA translation and protein synthesis Several activity-regulated translational control pathways have been demonstrated to participate in pathologies of autism, such as the ERK/MAPK (mitogen-activated protein kinase) 143 and PI3K/mTOR (mammalian target of rapamycin) pathways