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While it is generally accepted that opioid withdrawal is not fatal, iatrogenic precipitated withdrawal may be much more severe resulting in clinically significant autonomic hyperactivity with consequences such as pulmonary edema and make patients more reticent to continue with future medication for opioid use disorder

Next, to further verify the connection between CXCL10 and IL18R1 for PMF activation, we compared recombinant CXCL10 treatment and CXCL10 plus IL18R1 antibody treatment (10+18ab) in in vitro-cultured ovaries