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By integrating these disparate elements, our work emphasises the necessity of a holistic approach to diagnosing, researching, and treating ME/CFS, urging the scientific community to reconsider the diseases complexity and the multifaceted approach required for its study and management

Also, autaptic hippocampal cultures produced from these transgenic mice showed a decrease in both amplitude and frequency of EPSCs, whilst neurons of Mecp2 Tg1 mice, with an upregulated Mecp2 gene, had an opposite effect [377]