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Metabolites were separated on a Zorbax Eclipse XDB-C8 column (5 m, 4.6 150 mm) using gradient elution with water and acetonitrile as mobile phases
The crucial role of the substantia nigra dopaminergic neurons in operant conditioning for food emerged from data showing that selective restoration of dopamine production in substantia nigra or its primary terminal target, the dorsal striatum, is sufficient to restore the motivation to work for food in mice that lack dopamine otherwise (Sotak et al., 2005
doi: 10.1111/j.1600-065X.2011.01078.x 213 RegoliMManAGichevaNDumontAIvoryKPaciniAet al
It may also be responsible for toxicity and liver failure seen at lower doses (Amar 2007)
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