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Staying proactive about other weight management strategies, such as exercising, eating a balanced diet, and working with a team of weight loss professionals, can help minimize weight regain after stopping semaglutide.

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Simultaneously, there are disruptions in the expression of signaling pathways such as Transforming growth factor- (TGF-) signaling pathways, VEGF/VEGFR signaling pathways, Angiopoietin (Ang)/Tie signaling pathways, among others, ultimately driving glomerular fibrosis and progressing towards end-stage pathological conditions like glomerulosclerosis