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Cardiovascular benefits: Numerous studies have demonstrated that GLP-1s reduce cardiovascular risk in patients with diabetes or those at high cardiovascular risk, independent of their HbA1c levels

Semaglutide versus sitagliptin: in one set of analyses, we compared initiators of semaglutide with initiators of sitagliptin in patients at elevated cardiovascular risk with type 2 diabetes and obesity

Interventional trials using prebiotics and probiotics in PCOS have demonstrated improvements in insulin sensitivity and sometimes in menstrual regularity, suggesting that modifying the microbiota can beneficially influence both metabolism and HPO axis function [122]