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Because secretagogues amplify natural GH pulses rather than creating a pharmacokinetic peak from outside, dosing in the evening (near sleep onset) aligns the induced pulse with the body's largest natural nocturnal GH surge

Option (Evidence Strength: Grade C) Intravesical Instillations DMSO, heparin, and/or lidocaine may be administered as intravesical treatments (listed in alphabetical order