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Puri V, Nagpal M, Singh I, Singh M, Dhingra GA, Kampanart H, et al

Baclofen is a GABA-B receptor agonist (originally used as an antispasmodic) that has recently been licensed for use in France for the treatment of alcohol dependence and withdrawal

Interestingly, RipAYs enzymatic activity requires the activation by eukaryotic thioredoxins, which are highly abundant in plants during pathogen infection (Tada et al., 2008)

The situation changed dramatically when it was proposed to use NMR as a method for HDX detection (Dempsey, 2001), and NMR-based HDX detection was the leading technique in the field until the early 2000s, when mass spectrometry (MS) emerged as an extremely powerful alternative (Deng et al., 2016