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A separate Phase 2 trial also published in The New England Journal of Medicine in 2023 evaluated retatrutide in adults with type 2 diabetes, reporting meaningful reductions in HbA1c alongside weight loss, with hypoglycaemia rates that were low in the absence of insulin or sulfonylurea co-administration

However, direct evidence for this hypothesis is lacking, and currently, there is no oral GLP-1R agonist with effective blood-brain barrier-penetrating ability

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