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Additional reporting by James Cheyne.

Acknowledgments The authors thank the contributions of Asan Medical Library (University of Ulsan College of Medicine, Seoul, Republic of Korea) for providing search terms for the systematic review and Enago (www.enago.co.kr) for the English-language review

However, optimal performance was achieved at 100 mg/mL, where drug loading was about 9% and encapsulation efficiency exceeded 90%

1,2 This trial was not designed to evaluate the relative safety of Toujeo compared with Tresiba, and comparator adverse event rates are not an adequate basis for comparison rates between the products Hypoglycemia events can vary among studies based on study design, method of collecting data, and hypoglycemia definitions