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Overlapping Effects: Fluid Balance and Dehydration One of the most critical areas of concern when combining spironolactone and semaglutide is fluid balance

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The only sex-specific contraindication involves pregnancy and breastfeeding, where the unknown effects on fetal development and infant exposure through breast milk warrant avoidance absent specific medical supervision

there are little data on the safety of continued use of these agents in patients who develop an infection while on therapy, although anecdotal evidence suggests that they can safely be restarted in many cases after the infection has resolved