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While the liver plays a significant role in systemic glutathione metabolism, the central nervous system (CNS) maintains its own tightly regulated GSH pool, independent of peripheral control (3-4)

While HQ showed a dissociation constant 90-fold higher than L-tyrosine, KA exhibited a value of nearly 4000-fold higher than the natural substrate

A further theory relates to the ability of UA to form complexes with metal ions such as Fe(III) 6

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