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The order of treatments and measurements was also randomized

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Figure 1 4 Disease regulation by glucagon 4.1 Type 1 and type 2 diabetes mellitus (T1DM and T2DM) Glucagon receptor antagonists have effectively lowered blood glucose and HbA1c levels in patients with diabetes ( 4.2 Obesity and energy balance Beyond regulating glucose, glucagon also suppresses appetite through the livervagal nervehypothalamic axis and encourages thermogenesis by activating brown adipose tissue, thereby aiding weight loss ( 4.3 Lipid metabolism and energy expenditure In lipid metabolism, glucagon promotes lipolysis, boosts fatty acid oxidation and ketone body production, and inhibits hepatic lipogenesis to prevent lipid accumulation