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Indeed, computer model simulations demonstrate that weight-dependent heterosynaptic plasticity can robustly prevent runaway dynamics of synaptic weights and runaway activity of model neurons subject to widely different patterns of activity and equipped with widely different plasticity rules (Chen et al., Because of its weight dependence, heterosynaptic plasticity has a normalizing effect on synaptic weights, which prevents both excessive increases and excessive decreases of weights

Pegylated arginine arginase (PEG-BCT-100) showed promising tumor suppressive activity, survival advantage, and safety against advanced HCC in phase I clinical trials of combination chemotherapy (oxaliplatin and capecitabine)

The argument goes like this

Do you want to just set us up with of how that might be connected