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Association of biochemical B 12 deficiency with metformin therapy and vitamin B 12 supplements: The National Health and Nutrition Examination Survey, 1999-2006 Diabetes Care

Yes, all Kate Farms formulas are USDA certified organic

It also carries essentially no risk at the doses typically used in compounded formulations, making it a low-downside addition even when the benefit is uncertain

The neuroprotective mechanisms identified - reduction of oxidative stress, modulation of inflammatory cytokines, enhancement of nerve growth factor - are theoretically sound