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Studies show GSNO administration increases wound collagen content by 52.0% at day 5 and 47.5% at day 10 compared to controls, while maintaining physiological collagenolytic activity necessary for proper tissue remodeling
Moreover, regular follow-ups are essential, and supervised use is advised
The negative-selection framework suggests yessmall molecules escape the pharmacokinetic constraints (proteolytic degradation, low permeability, food effects) that limit oral peptides
In addition, all currently available GLP-1R therapies are peptide agonists, most of which require subcutaneous administration [140]
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