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ORCID: Affiliation: 13 Department of Biochemistry, Institute of Chemistry, University of So Paulo, Cidade Universitria, So Paulo CEP 05508-000, SP, Brazil 14 International Joint Research Center on Purinergic Signalling, School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, Sichuan, China These authors contributed equally to this work

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General Observations from Research Models: Clinical supervision is essential