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110,111 Whilst duration of NAC supplementation appears to be important, another potential cause for some of the heterogeneity observed in clinical trials may be the length of time patients have been suffering from schizophrenia, with those with a history of schizophrenia for 20 years or more responding best to NAC

40,41 Although the first major randomized clinical trial for this approach REDUCE LAP-HF II demonstrated no difference in cardiovascular outcomes between the group treated with IASD vs

Lack of protein may increase muscle loss, which can contribute to fatigue, he says