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However, the barriers limited permeability and highly active efflux transporters make drug delivery to the CNS challenging 1

It is an essential element for several proteins and enzymes and is involved in many biological processes: selenoprotein synthesis, antioxidant functions, maintenance of cellular redox state, oxidative damage repair, and thyroid hormone synthesis and metabolism

If administered by injection, local reactions such as redness, swelling, itching, or pain can occur, and improper technique can increase infection risk

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