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Importantly, individual responses to GBTs vary, and suboptimal outcomes (weight loss 5 % after 12 weeks of GBT) may warrant a reassessment of treatment strategies [29,136,137]

The best needle for B12 injection into fat tissue would be within the 4-5 mm size range, combined with a gauge of 30G or higher

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Its worth noting that most treatment discontinuations occurred during the rapid dose-escalation phase, suggesting that a more gradual dose-escalation strategy could potentially mitigate these issues